[CAS NO. 423145-35-1]  YUM70

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PRODUCTS SPECIFICATIONS [423145-35-1]

Catalog
SLK-S6193
Brand
Selleck
CAS
423145-35-1

DESCRIPTION [423145-35-1]

Overview

MDLMFCD02228856
Molecular Weight398.84
Molecular FormulaC21H19ClN2O4
SMILESCCCC(NC(C1=CC=C(OCO2)C2=C1)C3=CC(Cl)=C4C=CC=NC4=C3O)=O

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

1 mg5 mg10 mg
1 mM2.5073 mL12.5364 mL25.0727 mL
5 mM0.5015 mL2.5073 mL5.0145 mL
10 mM0.2507 mL1.2536 mL2.5073 mL
50 mM0.0501 mL0.2507 mL0.5015 mL

Description

YUM70 is a potent inhibitor of inhibitor with an IC50 of 1.5 μM. YUM70 induces endoplasmic reticulum (ER) stress-mediated apoptosis in pancreatic cancer.Although YUM70 inhibits GRP78 enzymatic activity, it increases the expression of GRP78 by increasing the chaperone translation mechanism.

Targets

GRP78 [1]
1.5 μM