[CAS NO. 1638250-96-0] ETC-159
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PRODUCTS SPECIFICATIONS [1638250-96-0]
Catalog
SLK-S6616
Brand
Selleck
CAS
1638250-96-0
DESCRIPTION [1638250-96-0]
Overview
| MDL | MFCD29472267 |
|---|---|
| Molecular Weight | 391.38 |
| Molecular Formula | C19H17N7O3 |
| SMILES | O=C(NC1=NN=C(C2=CC=CC=C2)C=C1)CN3C=NC(N(C)C(N4C)=O)=C3C4=O |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.5551 mL | 12.7753 mL | 25.5506 mL |
| 5 mM | 0.5110 mL | 2.5551 mL | 5.1101 mL |
| 10 mM | 0.2555 mL | 1.2775 mL | 2.5551 mL |
| 50 mM | 0.0511 mL | 0.2555 mL | 0.5110 mL |
Description
ETC-159 (ETC-1922159) is an orally available, potent inhibitor with an IC50 of 2.9 nM for inhibiting β-catenin reporter activity in STF3A cells.
Targets
| Porcn [1] |
In vitro
ETC-159 treatment causes decreased abundance of Wnt3a-stabilized β-catenin protein in both mouse L cells and HEK293 cells. ETC-159 inhibits β-catenin signaling in response to multiple active Wnts. ETC-159 inhibits mouse PORCN with an IC50 of 18.1 nM, whereas the IC50 for Xenopus Porcn is approximately fourfold higher (70 nM).
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