[CAS NO. 1254977-87-1] JNJ-42153605
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PRODUCTS SPECIFICATIONS [1254977-87-1]
Catalog
SLK-S6618
Brand
Selleck
CAS
1254977-87-1
DESCRIPTION [1254977-87-1]
Overview
| MDL | MFCD22199231 |
|---|---|
| Molecular Weight | 400.44 |
| Molecular Formula | C22H23F3N4 |
| SMILES | FC(C1=C(N2CCC(C3=CC=CC=C3)CC2)C=CN4C1=NN=C4CC5CC5)(F)F |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Description
JNJ-42153605 is a potent and selective positive allosteric modulator with an EC50 of 17 nM.
Targets
| mGlu2 receptor [1] |
| 17 nM(EC50) |
In vitro
JNJ-42153605 is found to not have agonist or antagonist activity toward other mGlu receptor subtypes up to 30 μM (>50-fold vs mGluR2) and also shows no or negligible affinity or activity at any of the targets in the CEREP panel of receptors (>100-fold selectivity for mGlu2 receptor).
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