[CAS NO. 1228690-36-5] AM 095

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PRODUCTS SPECIFICATIONS [1228690-36-5]

Catalog

SLK-S6633

Brand

Selleck

CAS

1228690-36-5

DESCRIPTION [1228690-36-5]

Overview

MDL	MFCD22665734
Molecular Weight	456.49
Molecular Formula	C27H24N2O5
SMILES	N(C(O[C@H](C)C1=CC=CC=C1)=O)C2=C(ON=C2C)C3=CC=C(C=C3)C4=CC=C(CC(O)=O)C=C4

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	2.1906 mL	10.9531 mL	21.9063 mL
5 mM	0.4381 mL	2.1906 mL	4.3813 mL
10 mM	0.2191 mL	1.0953 mL	2.1906 mL
50 mM	0.0438 mL	0.2191 mL	0.4381 mL

Description

AM095 is an antagonist of the with IC50 values of 0.98 and 0.73 μM for recombinant human and mouse LPA1, respectively.

Targets

LPA1 receptor ^[1]

In vitro

AM095 is a potent LPA1 receptor antagonist because it inhibited GTPγS binding to Chinese hamster ovary (CHO) cell membranes overexpressing recombinant human or mouse LPA1 with IC50 values of 0.98 and 0.73 μM, respectively, and exhibited no LPA1 agonism. In functional assays, AM095 inhibited LPA-driven chemotaxis of CHO cells overexpressing mouse LPA1 (IC50=778 nM) and human A2058 melanoma cells (IC50=233 nM).

References

[1] Swaney JS, et al. J Pharmacol Exp Ther. 2011, 336(3):693-700.

Synonyms

[1,1′-Biphenyl]-4-acetic acid, 4′-[3-methyl-4-[[[(1R)-1-phenylethoxy]carbonyl]amino]-5-isoxazolyl]-

4′-[3-Methyl-4-[[[(1R)-1-phenylethoxy]carbonyl]amino]-5-isoxazolyl][1,1′-biphenyl]-4-acetic acid

[4′-[3-Methyl-4-[[[((R)-1-phenylethyl)oxy]carbonyl]amino]isoxazol-5-yl]biphenyl-4-yl]acetic acid

(R)-2-(4′-(3-Methyl-4-(((1-phenylethoxy)carbonyl)amino)isoxazol-5-yl)-[1,1′-biphenyl]-4-yl)acetic acid