[CAS NO. 2003234-63-5] (R)-GNE-140
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PRODUCTS SPECIFICATIONS [2003234-63-5]
Store
Catalog
SLK-S6675
Brand
Selleck
CAS
2003234-63-5
DESCRIPTION [2003234-63-5]
Overview
| MDL | MFCD31560470 |
|---|---|
| Molecular Weight | 499.04 |
| Molecular Formula | C25H23ClN2O3S2 |
| SMILES | O=C1N[C@@](C2=CSC=C2)(C3=CC=C(N4CCOCC4)C=C3)CC(O)=C1SC5=CC=CC=C5Cl |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.0038 mL | 10.0192 mL | 20.0385 mL |
| 5 mM | 0.4008 mL | 2.0038 mL | 4.0077 mL |
| 10 mM | 0.2004 mL | 1.0019 mL | 2.0038 mL |
| 50 mM | 0.0401 mL | 0.2004 mL | 0.4008 mL |
Description
(R)-GNE-140 is a selective inhibitor of the and with IC50s of 3 nM and 5 nM, respectively. The R enantiomer of GNE-140 is 18-fold more potent than S enantiomer.
In vitro
(R)-GNE-140 inhibits proliferation in 37 of 347 cancer cell lines tested at a potency cut off of 5 μM. (R)-GNE-140 exhibits inhibition with two chondrosarcoma (bone) cancer cell lines that harbored IDH1 mutations (IC50 = 0.8μM).(R)-GNE-140 has submicromolar MiaPaca2 potency and inhibits proliferation in 11% of cancer cell lines in a broad panel.
References
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