[CAS NO. 1991986-30-1] ML364
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PRODUCTS SPECIFICATIONS [1991986-30-1]
Store
Catalog
SLK-S6748
Brand
Selleck
CAS
1991986-30-1
DESCRIPTION [1991986-30-1]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 517.54 |
| Molecular Formula | C24H18F3N3O3S2 |
| SMILES | O=C(NC1=NC(C2=CC=CC=C2)=CS1)C3=CC=C(C(F)(F)F)C=C3NS(=O)(C4=CC=C(C)C=C4)=O |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.9322 mL | 9.6611 mL | 19.3222 mL |
| 5 mM | 0.3864 mL | 1.9322 mL | 3.8644 mL |
| 10 mM | 0.1932 mL | 0.9661 mL | 1.9322 mL |
| 50 mM | 0.0386 mL | 0.1932 mL | 0.3864 mL |
Description
ML364 is a small molecule inhibitor of the with an IC50 of 1.1 μM in a biochemical assay using an internally quenched fluorescent di-ubiquitin substrate.
In vitro
ML364 induces an increase in cellular cyclin D1 degradation and causes cell cycle arrest in Mino and HCT116 cancer cell lines. ML364 is antiproliferative in cancer cell lines. ML364 also causes a decrease in homologous recombination-mediated DNA repair. It is inactive against caspase 6, caspase 7, MMP1, MMP9, and USP15, but does inhibit USP8 with an IC50 of 0.95 μM. In a panel of 102 kinases that included regulators of the cell cycle there is no binding observed to any of the enzymes tested using 10 μM ML364.
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