[CAS NO. 1126084-37-4] ASP-9521
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PRODUCTS SPECIFICATIONS [1126084-37-4]
Store
Catalog
SLK-S6749
Brand
Selleck
CAS
1126084-37-4
DESCRIPTION [1126084-37-4]
Overview
| MDL | MFCD30532740 |
|---|---|
| Molecular Weight | 330.42 |
| Molecular Formula | C19H26N2O3 |
| SMILES | O=C(N1CCC(CC1)CC(C)(O)C)C2=CC3=CC(OC)=CC=C3N2 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.0265 mL | 15.1323 mL | 30.2645 mL |
| 5 mM | 0.6053 mL | 3.0265 mL | 6.0529 mL |
| 10 mM | 0.3026 mL | 1.5132 mL | 3.0265 mL |
| 50 mM | 0.0605 mL | 0.3026 mL | 0.6053 mL |
Description
ASP-9521 is a selective, orally bioavailable inhibitor of .
Targets
| 17β-HSD5 [1] |
In vitro
In vitro, ASP9521 inhibited the conversion of androstenedione into testosterone by recombinant human and cynomolgus monkey AKR1C3 in a concentration-dependent manner, with IC50 values of 11 and 49 nmol/L, respectively. In contrast, ASP9521 did not inhibit the conversion by rat and mouse homologues (AKR1C1 and AKR1C6, respectively) up to a concentration of 10 μmol/L. ASP9521 showed moderately high selectivity (>100-fold) for human AKR1C3 (IC50: 120 nmol/L) over the human isoform AKR1C2 (IC50: >20,000 nmol/L).
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