[CAS NO. 1401728-56-0] NE 52-QQ57
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PRODUCTS SPECIFICATIONS [1401728-56-0]
Catalog
SLK-S6850
Brand
Selleck
CAS
1401728-56-0
DESCRIPTION [1401728-56-0]
Overview
| MDL | MFCD31813600 |
|---|---|
| Molecular Weight | 416.52 |
| Molecular Formula | C24H28N6O |
| SMILES | CC1=CC(C)=NC2=C(CC3=CC=C(C4=NN=C(C5CCNCC5)O4)C=C3)C(CC)=NN12 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.4008 mL | 12.0042 mL | 24.0085 mL |
| 5 mM | 0.4802 mL | 2.4008 mL | 4.8017 mL |
| 10 mM | 0.2401 mL | 1.2004 mL | 2.4008 mL |
| 50 mM | 0.0480 mL | 0.2401 mL | 0.4802 mL |
Description
NE 52-QQ57 is a selective, and orally available antagonist of with IC50 of 0.07 μM. NE 52-QQ57 effectively blocks GPR4-mediated cAMP accumulation with IC50 of 26.8 nM in HEK293 cells. The antagonism of GPR4 with NE 52-QQ57 significantly inhibits the AGE-induced increased expression of several key inflammatory cytokines and signaling molecules, including , , , , , , and .
Targets
References
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