[CAS NO. 303-45-7] Gossypol

Name: Gossypol
Brand: Arctom Scientific
SKU: SLK-S6852

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PRODUCTS SPECIFICATIONS [303-45-7]

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Catalog

SLK-S6852

Brand

Selleck

CAS

303-45-7

DESCRIPTION [303-45-7]

Overview

MDL	MFCD00017352
Molecular Weight	518.55
Molecular Formula	C30H30O8
SMILES	C(C)(C)C=1C2=C(C(C=O)=C(O)C1O)C(O)=C(C(C)=C2)C3=C(O)C4=C(C=C3C)C(C(C)C)=C(O)C(O)=C4C=O

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	1.9285 mL	9.6423 mL	19.2845 mL
5 mM	0.3857 mL	1.9285 mL	3.8569 mL
10 mM	0.1928 mL	0.9642 mL	1.9285 mL
50 mM	0.0386 mL	0.1928 mL	0.3857 mL

Description

Gossypol (BL 193) is an orally-active polyphenol isolated from cotton seeds and roots. Gossypol is a potent inhibitor of and with IC50 of 3.33 μM and 0.52 μM in cell-free assay, respectively. Gossypol also inhibits the binding of BH3 peptide to Bcl protein with IC50 of 0.4 μM and 10 μM for and , respectively. Gossypol induces and cell growth inhibition in various cancer cells.

Targets

Bcl-xL ^[3] (Cell-free assay)	3α-hydroxysteroid dehydrogenase ^[2] (Cell-free assay)	5α-reductase 1 ^[2] (Cell-free assay)	Bcl-2 ^[3] (Cell-free assay)
0.4 μM	0.52 μM	3.33 μM	10 μM

References

[1] Christopher L Oliver, et al. Mol Cancer Ther. 2005 Jan;4(1):23-31.
[2] Shuyan Cao, et al. Fitoterapia. 2019 Mar;133:102-108.
[3] Manchao Zhang, et al. Biochem Pharmacol. 2003 Jul 1;66(1):93-103.

Synonyms

[2,2′-Binaphthalene]-8,8′-dicarboxaldehyde, 1,1′,6,6′,7,7′-hexahydroxy-3,3′-dimethyl-5,5′-bis(1-methylethyl)-

[2,2′-Binaphthalene]-8,8′-dicarboxaldehyde, 1,1′,6,6′,7,7′-hexahydroxy-5,5′-diisopropyl-3,3′-dimethyl-

1,1′,6,6′,7,7′-Hexahydroxy-3,3′-dimethyl-5,5′-bis(1-methylethyl)[2,2′-binaphthalene]-8,8′-dicarboxaldehyde

2,2′-Bis[8-formyl-1,6,7-trihydroxy-5-isopropyl-3-methylnaphthyl]

2,2′-Bis[1,6,7-trihydroxy-3-methyl-5-isopropyl-8-aldehydonaphthyl]

Gossypol

1,1′,6,6′,7,7′-Hexahydroxy-5,5′-diisopropyl-3,3′-dimethyl-2,2′-binaphthalene-8,8′-dicarboxaldehyde

1,1′,6,6′,7,7′-Hexahydroxy-3,3′-dimethyl-5,5′-diisopropyl-2,2′-binaphthyl-8,8′-dialdehyde

1,1′,6,6′,7,7′-Hexahydroxy-3,3′-dimethyl-5,5′-diisopropyl[2,2′-binaphthalene]-8,8′-dicarboxaldehyde

Tash 1

(±)-Gossypol

Pogosin

No Fertil

NSC 56817

NSC 624336

1,6,7,1′,6′,7′-Hexahydroxy-5,5′-diisopropyl-3,3′-dimethyl-[2,2′]binaphthalenyl-8,8′-dicarboxaldehyde

BL 193