[CAS NO. 1394820-69-9]  Ningetinib

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PRODUCTS SPECIFICATIONS [1394820-69-9]

Catalog
SLK-S6870
Brand
Selleck
CAS
1394820-69-9

DESCRIPTION [1394820-69-9]

Overview

MDLMFCD28502048
Molecular Weight556.58
Molecular FormulaC31H29FN4O5
SMILESO=C(C1=C(C)N(C)N(C2=CC=CC=C2)C1=O)NC3=CC=C(OC4=CC=NC5=CC(OCC(C)(O)C)=CC=C45)C(F)=C3

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

1 mg5 mg10 mg
1 mM1.7967 mL8.9834 mL17.9669 mL
5 mM0.3593 mL1.7967 mL3.5934 mL
10 mM0.1797 mL0.8983 mL1.7967 mL
50 mM---

Description

Ningetinib (CT-053, DE-120, CT053PTSA) is a potent, orally bioavailable inhibitor of with IC50 of 6.7 nM, 1.9 nM and <1.0 nM for , and , respectively. Ningetinib exhibits antitumor activity.

Targets

Axl [1]
(Cell-free assay)
VEGFR2 [1]
(Cell-free assay)
c-Met [1]
(Cell-free assay)
1.0 nM1.9 nM6.7 nM