[CAS NO. 351986-85-1] Vacuolin-1
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PRODUCTS SPECIFICATIONS [351986-85-1]
Catalog
SLK-S6912
Brand
Selleck
CAS
351986-85-1
DESCRIPTION [351986-85-1]
Overview
| MDL | MFCD00321410 |
|---|---|
| Molecular Weight | 577.42 |
| Molecular Formula | C26H24IN7O |
| SMILES | IC1=CC(/C=N/NC2=NC(N(C3=CC=CC=C3)C4=CC=CC=C4)=NC(N5CCOCC5)=N2)=CC=C1 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.7318 mL | 8.6592 mL | 17.3184 mL |
| 5 mM | 0.3464 mL | 1.7318 mL | 3.4637 mL |
| 10 mM | 0.1732 mL | 0.8659 mL | 1.7318 mL |
| 50 mM | 0.0346 mL | 0.1732 mL | 0.3464 mL |
Description
Vacuolin-1 is a potent and cell-permeable inhibitor that blocks the and prevents the release of lysosomal content without affecting the process of resealing. Vacuolin-1 is also a potent and selective inhibitor, and inhibits by impairing lysosomal maturation via PIKfyve inhibition.
Targets
| PIKfyve [1] |
In vitro
Vacuolin-1 blocks both ionophore- and wound-induced, Ca-dependent exocytosis of lysosomes, but does not block Ca-dependent fusion of enlargeosomes with the plasma membrane.
References
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