[CAS NO. 314245-33-5] IU1
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PRODUCTS SPECIFICATIONS [314245-33-5]
Store
Catalog
SLK-S7134
Brand
Selleck
CAS
314245-33-5
DESCRIPTION [314245-33-5]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 300.37 |
| Molecular Formula | C18H21FN2O |
| SMILES | - |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.3292 mL | 16.6461 mL | 33.2923 mL |
| 5 mM | 0.6658 mL | 3.3292 mL | 6.6585 mL |
| 10 mM | 0.3329 mL | 1.6646 mL | 3.3292 mL |
| 50 mM | 0.0666 mL | 0.3329 mL | 0.6658 mL |
Description
IU1 is a cell-permeable, reversible and selective inhibitor of human with of 4.7 μ M, 25-fold selective to IsoT. IU1 induces .
Targets
| USP14 [1] (cell-free assay) |
| 4.7 μM |
In vitro
IU1 binds specifically to the activated form of USP14. IU1 can potentially inhibit USP14 by preventing its docking on the proteasome, exhibiting little or no activity toward 8 other DUBs, IsoT, UCH37, BAP1, UCH-L1, UCH-L3, USP15, USP2, USP7. USP14 inhibition is rapidly established upon addition of IU1 and rapidly reversed upon its removal. IU1 inhibits USP14 induced chain trimming and decreases electrophoretic mobility of Ub-CCNB species. IU1 enhances proteasomal degradation of Ub-CCNB in the presence of USP14. IU1 promots degradation of tau and depletes TDP-43, ATXN3, and glial fibrillary acidic protein (GFAP) in proteotoxic mechanisms.
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