[CAS NO. 890842-28-1] GSK650394
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PRODUCTS SPECIFICATIONS [890842-28-1]
Catalog
SLK-S7209
Brand
Selleck
CAS
890842-28-1
DESCRIPTION [890842-28-1]
Overview
| MDL | MFCD12828779 |
|---|---|
| Molecular Weight | 382.45 |
| Molecular Formula | C25H22N2O2 |
| SMILES | O=C(O)C1=CC=C(C2=CNC3=NC=C(C4=CC=CC=C4)C=C32)C=C1C5CCCC5 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.6147 mL | 13.0736 mL | 26.1472 mL |
| 5 mM | 0.5229 mL | 2.6147 mL | 5.2294 mL |
| 10 mM | 0.2615 mL | 1.3074 mL | 2.6147 mL |
| 50 mM | 0.0523 mL | 0.2615 mL | 0.5229 mL |
Description
GSK650394 is a serum- and glucocorticoid-regulated kinase-1 inhibitor with of 62 nM and 103 nM for and , respectively.
In vitro
GSK650394 inhibits SGK1-mediated epithelial transport with an IC50 of 0.6 μM in the SCC assay. In LNCaP cells, GSK650394 inhibits the androgen-mediated enhancement of Nedd4-2 phosphorylation and androgen-mediated cell growth. GSK650394 counteracts the Cortisol-induced decrease in neurogenesis, changes in Hedgehog signaling, and GR nuclear translocation. [2] GSK 650394 inhibits replication of influenza virus by impairing the export of influenza vRNPs into the cytoplasm of A549 cells.
References
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