[CAS NO. 848141-11-7] Alvelestat (AZD9668)
Please click "REQUEST A QUOTE" button if you need other sizes or custom synthesis
request a quote
If there is no stock, or you need other sizes or custom synthesis, please:
PRODUCTS SPECIFICATIONS [848141-11-7]
Store
Catalog
SLK-S7218
Brand
Selleck
CAS
848141-11-7
DESCRIPTION [848141-11-7]
Overview
| MDL | MFCD26960961 |
|---|---|
| Molecular Weight | 545.53 |
| Molecular Formula | C25H22F3N5O4S |
| SMILES | O=C(C1=CC(C2=CC=NN2C)=C(C)N(C3=CC=CC(C(F)(F)F)=C3)C1=O)NCC4=NC=C(S(=O)(C)=O)C=C4 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.8331 mL | 9.1654 mL | 18.3308 mL |
| 5 mM | 0.3666 mL | 1.8331 mL | 3.6662 mL |
| 10 mM | 0.1833 mL | 0.9165 mL | 1.8331 mL |
| 50 mM | 0.0367 mL | 0.1833 mL | 0.3666 mL |
Description
Alvelestat (AZD9668, Avelestat) is an oral, highly selective inhibitor of with and of 12 nM and 9.4 nM, at least 600-fold more selective over other serine proteases.
Phase 2.
Targets
In vitro
AZD9668 inhibits plasma NE activity in zymosan-stimulated whole blood, and also inhibits NE activity on the surface of stimulated polymorphonuclear cells and in the supernatant of primed, stimulated cells.
In vivo
In mice and rats, AZD9668 (p.o.) prevents human NE-induced lung injury. In a mouse model of smoke-induced airway inflammation, AZD9668 significantly reduces the number of BAL neutrophils and BAL IL-1β. In a guinea pig chronic smoke model, AZD9668 prevents airspace enlargement and small airway wall remodeling in guinea pigs in response to chronic tobacco smoke exposure.
Powered by Arctom Copyright © 2026 Arctom. All rights
reserved.