[CAS NO. 864953-29-7] Fostemsavir

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PRODUCTS SPECIFICATIONS [864953-29-7]

Catalog

SLK-S7220

Brand

Selleck

CAS

864953-29-7

DESCRIPTION [864953-29-7]

Overview

MDL	-
Molecular Weight	583.49
Molecular Formula	C25H26N7O8P
SMILES	C(OP(=O)(O)O)N1C=2C(C(C(C(=O)N3CCN(C(=O)C4=CC=CC=C4)CC3)=O)=C1)=C(OC)C=NC2N5N=C(C)N=C5

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Description

Fostemsavir (BMS-663068, Rukobia), the phosphonooxymethyl prodrug of BMS626529, is an attachment inhibitor that targets and prevents its binding to CD4+ T cells with of < 10 nM.

Targets

HIV-1 gp120 ^[1]
(Cell-free assay)

10 nM(EC50)

References

[1] Beata Nowicka-Sans, et al. Antimicrob Agents Chemother. 2012 Jul;56(7):3498-507.
[2] Min Li, et al. Nat Commun. 2020 Aug 13;11(1):4051.

Synonyms

1,2-Ethanedione, 1-(4-benzoyl-1-piperazinyl)-2-[4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1-[(phosphonooxy)methyl]-1H-pyrrolo[2,3-c]pyridin-3-yl]-

Piperazine, 1-benzoyl-4-[[4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1-[(phosphonooxy)methyl]-1H-pyrrolo[2,3-c]pyridin-3-yl]oxoacetyl]-

1-(4-Benzoyl-1-piperazinyl)-2-[4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-yl)-1-[(phosphonooxy)methyl]-1H-pyrrolo[2,3-c]pyridin-3-yl]-1,2-ethanedione

Fostemsavir

BMS 663068

Rukobia