[CAS NO. 14003-96-4] 4μ8C

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PRODUCTS SPECIFICATIONS [14003-96-4]

Catalog

SLK-S7272

Brand

Selleck

CAS

14003-96-4

DESCRIPTION [14003-96-4]

Overview

MDL	MFCD12027255
Molecular Weight	204.18
Molecular Formula	C11H8O4
SMILES	O=CC1=C(O)C=CC2=C1OC(C=C2C)=O

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	4.8976 mL	24.4882 mL	48.9764 mL
5 mM	0.9795 mL	4.8976 mL	9.7953 mL
10 mM	0.4898 mL	2.4488 mL	4.8976 mL
50 mM	0.0980 mL	0.4898 mL	0.9795 mL

Description

4μ8C (IRE1 Inhibitor III) is a potent and selective inhibitor with of 76 nM.

Features

IRE1 Rnase-selective inhibitor, used as a platform for developing new locally acting drugs.

Targets

IRE1 Rnase ^[1]
(Cell-free assay)

76 nM

In vitro

4μ8C blocks substrate(RIDD) access to the active site of IRE1 and selectively inactivates both Xbp1 splicing and IRE1-mediated mRNA degradation. IRE1 inhibition subsequently induces ER stress without measureable acute toxicity. 4μ8C, as an IRE1 inhibitor, blocks IL-4, IL-5, and IL-13 production from CD4+ T cells.

References

[1] Cross BC, et al. Proc Natl Acad Sci U S A. 2012, 109(15), E869-878.
[2] Kemp KL, et al. J Biol Chem. 2013, 288(46), 33272-33282.
[3] Tufanli O, et al. Proc Natl Acad Sci U S A. 2017 Feb 21;114(8):E1395-E1404.