[CAS NO. 199596-05-9] JIB-04
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PRODUCTS SPECIFICATIONS [199596-05-9]
Catalog
SLK-S7281
Brand
Selleck
CAS
199596-05-9
DESCRIPTION [199596-05-9]
Overview
| MDL | MFCD26936344 |
|---|---|
| Molecular Weight | 308.76 |
| Molecular Formula | C17H13ClN4 |
| SMILES | ClC1=CN=C(N/N=C(C2=CC=CC=C2)/C3=NC=CC=C3)C=C1 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.2388 mL | 16.1938 mL | 32.3876 mL |
| 5 mM | 0.6478 mL | 3.2388 mL | 6.4775 mL |
| 10 mM | 0.3239 mL | 1.6194 mL | 3.2388 mL |
| 50 mM | 0.0648 mL | 0.3239 mL | 0.6478 mL |
Description
JIB-04 (NSC 693627) is a pan-selective inhibitor with of 230, 340, 855, 445, 435, 1100, and 290 nM for JARID1A, JMJD2E, JMJD3, JMJD2A, JMJD2B, JMJD2C, and JMJD2D in cell-free assays, respectively. JIB‑04 also induces cell .
Targets
In vitro
JIB-04 induces transcriptional changes in a cancer-selective manner, including the downregulation of proliferative genes and the upregulation of the anti-proliferative/pro-apoptotic genes. JIB-04 blocks growth of lung and prostate cancer lines with IC50 as low as 10 nM, while produces less anti-proliferative activities on HBECs and PrSCs/PrECs.
In vivo
In two separate xenograft mouse models (H358 or A549), JIB-04 diminishes tumor growth, lowers Jumonji histone demethylase activity in tumors, and prolongs cancer survival.
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