[CAS NO. 1418013-75-8] NMS-873

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PRODUCTS SPECIFICATIONS [1418013-75-8]

Catalog

SLK-S7285

Brand

Selleck

CAS

1418013-75-8

DESCRIPTION [1418013-75-8]

Overview

MDL	-
Molecular Weight	520.67
Molecular Formula	C27H28N4O3S2
SMILES	O=S(C1=CC=C(C2=CC=C(OCC3=NN=C(SC4CCCC4)N3C5=CC=CN=C5)C=C2C)C=C1)(C)=O

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	1.9206 mL	9.6030 mL	19.2060 mL
5 mM	0.3841 mL	1.9206 mL	3.8412 mL
10 mM	0.1921 mL	0.9603 mL	1.9206 mL
50 mM	0.0384 mL	0.1921 mL	0.3841 mL

Description

NMS-873 is an allosteric and specific inhibitor with of 30 nM that demonstrates potent selectivity for VCP/p97 compared to a panel of other AAA ATPases, Hsp90, and 53 additional analyzed kinases (IC50s >10 μM).

Features

The most potent and specific p97 inhibitor described to date.

Targets

p97 ^[1]
(Cell-free assay)

30 nM

In vitro

NMS-873 reduces p97 sensitivity to trypsin digestion, preventing degradation of the linker-D2 domain. NMS-873, as a p97 inhibitor, produces antiproliferative activity in a variety of hematological and solid tumor lines. The mechanism study indicates that NMS-873 activates the unfolded protein response, interfers with autophagy and thus induces cancer cell death.

References

[1] Magnaghi P, et al. Nat Chem Biol. 2013, 9(9), 548-556.