[CAS NO. 1627607-87-7] PFI-2 HCl

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PRODUCTS SPECIFICATIONS [1627607-87-7]

Catalog

SLK-S7294

Brand

Selleck

CAS

1627607-87-7

DESCRIPTION [1627607-87-7]

Overview

MDL	MFCD28133380
Molecular Weight	535.98
Molecular Formula	C23H25F4N3O3S.HCl
SMILES	O=S(C1=CC2=C(CNCC2)C(F)=C1)(N[C@H](CC3=CC=CC(C(F)(F)F)=C3)C(N4CCCC4)=O)=O.[H]Cl

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	1.8657 mL	9.3287 mL	18.6574 mL
5 mM	0.3731 mL	1.8657 mL	3.7315 mL
10 mM	0.1866 mL	0.9329 mL	1.8657 mL
50 mM	0.0373 mL	0.1866 mL	0.3731 mL

Description

PFI-2 is a potent, selective, and cell-active inhibitor with and of 0.33 nM and 2 nM, 1000-fold selectivity over other methyltransferases and other non-epigenetic targets.

Targets

SETD7 ^[1] (Cell-free assay)	SETD7 ^[1] (Cell-free assay)
0.33 nM(Ki)	2 nM

In vitro

(R)-PFI-2 shows 500-fold more inhibitory activity against human SETD7 than its enantiomer, (S)-PFI-2. In a cellular environment, through direct interactions with SETD7, affects Yes-Associated protein localization and phenocopies Setd7 genetic deletion on Hippo pathway signaling.

References

[1] Barsyte-Lovejoy D, et al. Proc Natl Acad Sci U S A. 2014, 111(35), 12853-12858.