[CAS NO. 1427782-89-5] IWP-L6
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PRODUCTS SPECIFICATIONS [1427782-89-5]
Catalog
SLK-S7301
Brand
Selleck
CAS
1427782-89-5
DESCRIPTION [1427782-89-5]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 472.58 |
| Molecular Formula | C25H20N4O2S2 |
| SMILES | - |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.1160 mL | 10.5802 mL | 21.1604 mL |
| 5 mM | 0.4232 mL | 2.1160 mL | 4.2321 mL |
| 10 mM | 0.2116 mL | 1.0580 mL | 2.1160 mL |
| 50 mM | 0.0423 mL | 0.2116 mL | 0.4232 mL |
Description
IWP-L6 (Porcn Inhibitor III) is a highly potent inhibitor with of 0.5 nM.
Targets
| Porcn [1] |
| 0.5 nM(EC50) |
In vitro
IWP-L6 blocks the phosphorylation of the cytoplasmic Wnt pathway effector Dvl2 in HEK293 cells. In cultured embryonic kidneys, IWP-L6 also inhibits Wnt mediated branching morphogenesis by reversibly blocking Wnt signaling.
In vivo
IWP-L6 is stable in human plasma over 24 h, while rapidly metabolized in rat plasma (t1/2 = 190 min), murine plasma (t1/2 = 2 min), and the murine liver S9 fractions. In embryonic zebrafish, IWP-L6 effectively inhibits posterior axis formation, a Wnt/β-catenin dependent developmental process.
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