[CAS NO. 1493764-08-1] UNC2881

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PRODUCTS SPECIFICATIONS [1493764-08-1]

Catalog

SLK-S7325

Brand

Selleck

CAS

1493764-08-1

MDL	MFCD28142814
Molecular Weight	463.58
Molecular Formula	C25H33N7O2
SMILES	O=C(C1=CN=C(NCCCC)N=C1N[C@H]2CC[C@H](O)CC2)NCC3=CC=C(N4C=CN=C4)C=C3

For research use only.

3 years,-20°C,powder
1 years,-80°C,in solvent

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

UNC2881 is a specific inhibitor with of 4.3 nM, about 83- and 58-fold selectivity over Axl and Tyro3, respectively.

Mer ^[1] (Cell-free assay)	Tyro3 ^[1] (Cell-free assay)	Axl ^[1] (Cell-free assay)
4.3 nM	250 nM	360 nM

UNC2881 inhibits Mer kinase activity in 697 B-ALL cells with IC50 of 22 nM, and inhibits collagen-stimulated platelet aggregation.

UNC2881 have high systemic clearance (94.5 mL/min/kg) and 14% oral bioavailability in mice.