[CAS NO. 1594094-64-0] CW069
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PRODUCTS SPECIFICATIONS [1594094-64-0]
Catalog
SLK-S7336
Brand
Selleck
CAS
1594094-64-0
DESCRIPTION [1594094-64-0]
Overview
| MDL | MFCD28009372 |
|---|---|
| Molecular Weight | 500.33 |
| Molecular Formula | C23H21IN2O3 |
| SMILES | IC1=CC(C(O)=O)=C(C=C1)NC([C@@H](NCC2=CC=CC=C2)CC3=CC=CC=C3)=O |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.9987 mL | 9.9934 mL | 19.9868 mL |
| 5 mM | 0.3997 mL | 1.9987 mL | 3.9974 mL |
| 10 mM | 0.1999 mL | 0.9993 mL | 1.9987 mL |
| 50 mM | 0.0400 mL | 0.1999 mL | 0.3997 mL |
Description
CW069 is an allosteric, and selective inhibitor of with of 75 μM, significant selectivity over KSP.
Features
Allosteric, HSET-selective inhibitor.
Targets
| HSET [1] |
| 75 μM |
In vitro
CW069 increases multipolar spindles in N1E-115 cells with supernumerary centrosomes without altering bipolar spindle morphology in normal human dermal fibroblast cells. CW069 inhibits growth in cancer N1E-115 cells with IC50 of 10 μM, but not in NHDF or primary human bone marrow cells.
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