[CAS NO. 1493694-70-4] UNC2250
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PRODUCTS SPECIFICATIONS [1493694-70-4]
Distributor
Catalog
SLK-S7342
Brand
Selleck
CAS
1493694-70-4
DESCRIPTION [1493694-70-4]
Overview
| MDL | MFCD27992060 |
|---|---|
| Molecular Weight | 440.58 |
| Molecular Formula | C24H36N6O2 |
| SMILES | O[C@H]1CC[C@H](NC2=NC(NCCCC)=NC=C2C3=NC=C(CN4CCOCC4)C=C3)CC1 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.2697 mL | 11.3487 mL | 22.6974 mL |
| 5 mM | - | - | - |
| 10 mM | - | - | - |
| 50 mM | - | - | - |
Description
UNC2250 is a potent and selective inhibitor with of 1.7 nM, about 160- and 60-fold selectivity over the closely related kinases Axl/Tyro3.
In vitro
UNC2250 efficiently inhibits Mer phosphorylation in 697 B-ALL cells and Colo699 NSCLC cells. Moreover, UNC2250 also displays functional antitumor activity by reducing colony-forming potential in both rhabdoid tumor cells and NSCLC cells.
In vivo
According to in vivo PK experiment, UNC2250 has a moderate half-life, clearance, and volume of distribution as well as reasonable oral bioavailability and good solubility.
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