[CAS NO. 924416-43-3] AdipoRon

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PRODUCTS SPECIFICATIONS [924416-43-3]

Catalog

SLK-S7365

Brand

Selleck

CAS

924416-43-3

DESCRIPTION [924416-43-3]

Overview

MDL	MFCD08271060
Molecular Weight	428.52
Molecular Formula	C27H28N2O3
SMILES	O=C(NC1CCN(CC2=CC=CC=C2)CC1)COC3=CC=C(C(C4=CC=CC=C4)=O)C=C3

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	2.3336 mL	11.6681 mL	23.3361 mL
5 mM	0.4667 mL	2.3336 mL	4.6672 mL
10 mM	0.2334 mL	1.1668 mL	2.3336 mL
50 mM	0.0467 mL	0.2334 mL	0.4667 mL

Description

AdipoRon (SC-396658) is a novel, and orally bioavailable agonist with of 1.8 and 3.1 μM for AdipoR1 and AdipoR2, respectively.

Features

Orally bioavailable adiponectin receptor agonist that can be used for the treatment of obesity-related diseases.

Targets

AdipoR1 ^[1]	AdipoR2 ^[1]
1.8 μM(Kd)	3.1 μM(Kd)

In vitro

AdipoRon increases AMPK activation, PGC-1α expression and mitochondrial biogenesis by binding to both AdipoR1 and AdipoR2 in C2C12 myotubes.

In vivo

In skeletal muscle and liver of wild-type mice AdipoRon (50 mg/kg, i.v.) significantly induces phosphorylation of AMPK via AdipoR1 and AdipoR2. In WT mice, AdipoRon (50 mg/kg, p.o.) improves insulin resistance, glucose intolerance and dyslipidaemia by activating AdipoR1–AMPK–PGC-1α pathways in skeletal muscle, while by activating AdipoR2–PPAR-α pathways in the liver. Moreover, AdipoRon ameliorates diabetes of genetically obese rodent model db/db mice, and prolongs the shortened lifespan of db/db mice on a high-fat diet.

References

[1] Okada-Iwabu M, et al. Nature. 2013, 503(7477), 493-499.