[CAS NO. 886047-22-9] LY2119620

Name: LY2119620
Brand: Arctom Scientific
SKU: SLK-S7366

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PRODUCTS SPECIFICATIONS [886047-22-9]

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Catalog

SLK-S7366

Brand

Selleck

CAS

886047-22-9

DESCRIPTION [886047-22-9]

Overview

MDL	MFCD27996043
Molecular Weight	437.94
Molecular Formula	C19H24ClN5O3S
SMILES	O=C(C1=C(N)C2=C(C)C(Cl)=C(OCC(N3CCN(C)CC3)=O)N=C2S1)NC4CC4

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	2.2834 mL	11.4171 mL	22.8342 mL
5 mM	0.4567 mL	2.2834 mL	4.5668 mL
10 mM	0.2283 mL	1.1417 mL	2.2834 mL
50 mM	0.0457 mL	0.2283 mL	0.4567 mL

Description

LY2119620 is a specific, and allosteric agonist of human .

Targets

M2 muscarinic acetylcholine receptor ^[1]

M4 muscarinic acetylcholine receptor ^[1]

In vitro

LY2119620 displays modest allosteric agonism and positively modulates the functional G protein–signaling ability of an agonist at the M2/M4 receptor subtypes by placing the M2 and M4 receptors into an active G protein–bound state. LY2119620 enhances the potency of three muscarinic acetylcholine receptor agonists, ACh, Oxo-M and iperoxo. [H]LY2119620 can be used as a probe for the human M(2) and M(4) muscarinic receptor allosteric binding sites.

References

[1] Croy CH, et al. Mol Pharmacol. 2014, 86(1), 106-115.
[2] Schober DA, et al. Mol Pharmacol. 2014, 86(1), 116-123.