[CAS NO. 30827-99-7] AEBSF HCl
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PRODUCTS SPECIFICATIONS [30827-99-7]
Store
Catalog
SLK-S7378
Brand
Selleck
CAS
30827-99-7
DESCRIPTION [30827-99-7]
Overview
| MDL | MFCD00132962 |
|---|---|
| Molecular Weight | 239.69 |
| Molecular Formula | C8H11ClFNO2S |
| SMILES | S(F)(=O)(=O)C1=CC=C(CCN)C=C1.Cl |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 4.1721 mL | 20.8603 mL | 41.7206 mL |
| 5 mM | 0.8344 mL | 4.1721 mL | 8.3441 mL |
| 10 mM | 0.4172 mL | 2.0860 mL | 4.1721 mL |
| 50 mM | 0.0834 mL | 0.4172 mL | 0.8344 mL |
Description
AEBSF HCl is a broad spectrum, irreversible inhibitor.
Features
Broad spectrum, irreversible serine protease inhibitor.
Targets
| serine protease [1] |
In vitro
AEBSF inhibits the constitutive production of Aβ by directly inhibiting β-secretase in five different human cell lines, both neural and nonneural. AEBSF, as a serine protease inhibitor, inhibits the lysis of leukemic cells by human macrophages without inhibiting macrophage secretion of TNF-α and IL-1β. AEBSF also disturbs the growth of blastocysts on endometrial cells and inhibit the adhesion of HeLa cells on HUVECs by altering the protein secretion pattern.
In vivo
AEBSF (76.8 mg/kg daily i.p.) results in prolongation of the survival of mice that have been given a lethal T. gondii infection. AEBSF also reduces airway response and underlying inflammation in cockroach allergen-induced murine model.
References
[1] Citron M, et al. Neuron. 1996, 17(1), 171-179.
[2] Nakabo Y, et al. J Leukoc Biol. 1996, 60(3), 328-336.
[3] Buitrago-Rey R. et al. J Antimicrob Chemother. 2002, 49(5), 871-874.
[4] Jiang YH, et al. Contraception. 2011, 84(6), 642-648.
[5] Saw S, et al. Inflammation. 2014. DOI 10.1007/s10753-014-9976-0.
[2] Nakabo Y, et al. J Leukoc Biol. 1996, 60(3), 328-336.
[3] Buitrago-Rey R. et al. J Antimicrob Chemother. 2002, 49(5), 871-874.
[4] Jiang YH, et al. Contraception. 2011, 84(6), 642-648.
[5] Saw S, et al. Inflammation. 2014. DOI 10.1007/s10753-014-9976-0.
Synonyms
Benzenesulfonyl fluoride, 4-(2-aminoethyl)-, hydrochloride (1:1)
Benzenesulfonyl fluoride, 4-(2-aminoethyl)-, hydrochloride
Benzenesulfonyl fluoride, p-(2-aminoethyl)-, hydrochloride
Pefabloc
4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride
Pefabloc SC
Pefabloc SC Plus
AEBSF
(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride
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