[CAS NO. 103476-89-7] Leupeptin Hemisulfate
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PRODUCTS SPECIFICATIONS [103476-89-7]
Store
Catalog
SLK-S7380
Brand
Selleck
CAS
103476-89-7
DESCRIPTION [103476-89-7]
Overview
| MDL | MFCD00037012 |
|---|---|
| Molecular Weight | 475.59 |
| Molecular Formula | C20H38N6O4.1/2H2SO4 |
| SMILES | S(=O)(=O)(O)O.[C@@H](NC([C@H](CC(C)C)NC(C)=O)=O)(C(N[C@@H](CCCNC(=N)N)C=O)=O)CC(C)C |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.1027 mL | 10.5133 mL | 21.0265 mL |
| 5 mM | 0.4205 mL | 2.1027 mL | 4.2053 mL |
| 10 mM | 0.2103 mL | 1.0513 mL | 2.1027 mL |
| 50 mM | 0.0421 mL | 0.2103 mL | 0.4205 mL |
Description
Leupeptin Hemisulfate is a reversible inhibitor of and . It inhibits cathepsin B (Ki = 6 nM), calpain (Ki = 10 nM), trypsin (Ki = 35 nM), plasmin (Ki = 3.4 μM), and kallikrein (Ki = 19 μM), and has no effect against chymotrypsin, elastase, renin, or pepsin.
In vitro
Leupeptin, produced by various species of actinomycetes, strongly inhibit proteolysis. Leupeptin hemisulfate protects tubulin from endogenous proteolytic activities during the isolation procedure and results in increased tubulin purity. Leupeptin hemisulfate could restore up to 50% of hepatitis B surface antigen (HBsAg) expression in cell suspension cultures.
References
Synonyms
L-Leucinamide, N-acetyl-L -leucyl-N-[(1S)-4-[(aminoiminomethyl)amino]-1-formylbutyl]-, sulfate (2:1)
L-Leucinamide, N-acetyl-L -leucyl-N-[4-[(aminoiminomethyl)amino]-1-formylbutyl]-, (S)-, sulfate (2:1)
Leupeptin hemisulfate
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