[CAS NO. 164204-38-0] Phosphoramidon Disodium Salt
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PRODUCTS SPECIFICATIONS [164204-38-0]
Catalog
SLK-S7382
Brand
Selleck
CAS
164204-38-0
DESCRIPTION [164204-38-0]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 589.48 |
| Molecular Formula | C23H34N3Na2O10P |
| SMILES | O=C([O-])[C@@H](/N=C([O-])/[C@@H](NP(O[C@H]1[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O1)(O)=O)CC(C)C)CC2=CNC3=C2C=CC=C3.[Na+].[Na+] |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.6964 mL | 8.4821 mL | 16.9641 mL |
| 5 mM | 0.3393 mL | 1.6964 mL | 3.3928 mL |
| 10 mM | 0.1696 mL | 0.8482 mL | 1.6964 mL |
| 50 mM | 0.0339 mL | 0.1696 mL | 0.3393 mL |
Description
Phosphoramidon Disodium Salt is a inhibitor, widely used as a biochemical tool. Phosphoramidon inhibited activities with IC50 values of 3.5 μM, 0.034 μM, and 78 μM, respectively.
Targets
| metalloendopeptidase [1] |
In vitro
Phosphoramidon is a powerful inhibitor of thermolysin without inhibiting the other endopeptidases such as trypsin, papain, chymotrypsin. Phosphoramidon reduces tumor cell invasion in CC531 cells.
In vivo
In rats bearing colon carcinoma CC531 xenografts, Phosphoramidon (250 mg/Rat i.p.) significantly reduces tumor cell growth. Intranasal phosphoramidon increases beta-amyloid levels in wild-type and NEP/NEP2-deficient mice, and thus can be use to model Alzheimer's disease (AD).
References
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