[CAS NO. 1597403-47-8] ISRIB (trans-isomer)
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PRODUCTS SPECIFICATIONS [1597403-47-8]
Catalog
SLK-S7400
Brand
Selleck
CAS
1597403-47-8
DESCRIPTION [1597403-47-8]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 451.34 |
| Molecular Formula | C22H24Cl2N2O4 |
| SMILES | N(C(COC1=CC=C(Cl)C=C1)=O)[C@H]2CC[C@H](NC(COC3=CC=C(Cl)C=C3)=O)CC2 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.2156 mL | 11.0781 mL | 22.1562 mL |
| 5 mM | 0.4431 mL | 2.2156 mL | 4.4312 mL |
| 10 mM | 0.2216 mL | 1.1078 mL | 2.2156 mL |
| 50 mM | - | - | - |
Description
ISRIB (trans-isomer), the trans-isomer of ISRIB, is a potent and selective inhibitor with of 5 nM and does not have global effects on translation, transcription, or mRNA stability in non-stressed cells.
Targets
| PERK [1] (Cell-free assay) |
| 5 nM |
In vitro
ISRIB blocks production of endogenous ATF4, whereas XBP1 mRNA splicing and XBP1s production persisted. ISRIB prevents cells from re-establishing ER homeostasis by blocking signaling through the PERK branch of the UPR, and decreases the viability of cells that are subjected to ER-stress.
Synonyms
Acetamide, N,N′-trans-1,4-cyclohexanediylbis[2-(4-chlorophenoxy)-
N,N′-trans-1,4-Cyclohexanediylbis[2-(4-chlorophenoxy)acetamide]
SMDC 750213
ISRIB
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