[CAS NO. 84573-16-0] Rocaglamide

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PRODUCTS SPECIFICATIONS [84573-16-0]

Catalog

SLK-S7428

Brand

Selleck

CAS

84573-16-0

DESCRIPTION [84573-16-0]

Overview

MDL	MFCD08702699
Molecular Weight	505.56
Molecular Formula	C29H31NO7
SMILES	O[C@]12[C@]([C@@]([C@@H](C(N(C)C)=O)[C@H]1O)(C3=CC=CC=C3)[H])(OC=4C2=C(OC)C=C(OC)C4)C5=CC=C(OC)C=C5

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	1.9780 mL	9.8900 mL	19.7800 mL
5 mM	0.3956 mL	1.9780 mL	3.9560 mL
10 mM	0.1978 mL	0.9890 mL	1.9780 mL
50 mM	0.0396 mL	0.1978 mL	0.3956 mL

Description

Rocaglamide (Roc-A), isolated from Aglaia species, is a potent inhibitor of activation with IC50 of ~50 nM for HSF1. Rocaglamide inhibits the function of the translation initiation factor . Rocaglamide also inhibits activity. Rocaglamide exhibits anti-tumor activity.

Targets

eIF4A ^[1]	NF-κB ^[2]	HSF1 ^[1] (Cell-free assay)
		50 nM

In vitro

Rocaglamide A inhibits the heat shock reporter with IC50 of ~50 nM and inhibits the function of the translation initiation factor eIF4A, a DEAD box RNA helicase. Rocaglamides are able to suppress the PMA-induced expression of NF-kappaB target genes and sensitize leukemic T cells to apoptosis induced by TNFalpha, cisplatin, and gamma-irradiation.

References

[1] Sandro Santagata, et al. Science. 2013 Jul 19;341(6143):1238303.
[2] Bernd Baumann, et al. J Biol Chem. 2002 Nov 22;277(47):44791-800.
[3] Zhou Luan, et al. Mol Med Rep. 2015 Jan;11(1):203-11.

Synonyms

1H-Cyclopenta[b]benzofuran-2-carboxamide, 2,3,3a,8b-tetrahydro-1,8b-dihydroxy-6,8-dimethoxy-3a-(4-methoxyphenyl)-N,N-dimethyl-3-phenyl-, (1R,2R,3S,3aR,8bS)-

1H-Cyclopenta[b]benzofuran-2-carboxamide, 2,3,3a,8b-tetrahydro-1,8b-dihydroxy-6,8-dimethoxy-3a-(4-methoxyphenyl)-N,N-dimethyl-3-phenyl-, [1R-(1α,2α,3β,3aβ,8bβ)]-

(1R,2R,3S,3aR,8bS)-2,3,3a,8b-Tetrahydro-1,8b-dihydroxy-6,8-dimethoxy-3a-(4-methoxyphenyl)-N,N-dimethyl-3-phenyl-1H-cyclopenta[b]benzofuran-2-carboxamide

Rocaglamide

NSC 326408

Roc-A

Rocaglamide A

(-)-Rocaglamide