[CAS NO. 1472611-44-1] Pyridostatin (RR82) Trifluoroacetate Salt
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PRODUCTS SPECIFICATIONS [1472611-44-1]
Catalog
SLK-S7444
Brand
Selleck
CAS
1472611-44-1
DESCRIPTION [1472611-44-1]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 710.7 |
| Molecular Formula | C31H32N8O5·C2HF3O2 |
| SMILES | O=C(C1=NC(C(NC2=NC3=CC=CC=C3C(OCCN)=C2)=O)=CC(OCCN)=C1)NC4=NC5=CC=CC=C5C(OCCN)=C4.O=C(O)C(F)(F)F |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.4071 mL | 7.0353 mL | 14.0706 mL |
| 5 mM | 0.2814 mL | 1.4071 mL | 2.8141 mL |
| 10 mM | 0.1407 mL | 0.7035 mL | 1.4071 mL |
| 50 mM | 0.0281 mL | 0.1407 mL | 0.2814 mL |
Description
Pyridostatin Trifluoroacetate Salt (RR82) is a stabilizer with of 490 nM in a cell-free assay, which targets a series of proto-oncogenes.
Targets
| G-quadruplexe [1] (Cell-free assay) |
| 490 nM(Kd) |
In vitro
Pyridostatin decreases the proliferation of MRC-5–SV40 cells and various cancer cell lines, and induces cell-cycle arrest by DNA-damage checkpoint activation. Pyridostatin also reduces SRC-dependent cell motility in MDA-MB-231 cells by interacting with G-quadruplex motifs in SRC. Pyridostatin decreases EBNA1 synthesis via inhibition of G-quadruplexes.
References
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