[CAS NO. 940289-57-6] VER-49009
Please click "REQUEST A QUOTE" button if you need other sizes or
custom synthesis
request a quote
If there is no stock, or you need other sizes or custom synthesis,
please:
PRODUCTS SPECIFICATIONS [940289-57-6]
Catalog
SLK-S7458
Brand
Selleck
CAS
940289-57-6
DESCRIPTION [940289-57-6]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 387.82 |
| Molecular Formula | C19H18ClN3O4 |
| SMILES | CCNC(=O)C1=C(C(=NN1)C2=CC(=C(C=C2O)O)Cl)C3=CC=C(C=C3)OC |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.5785 mL | 12.8926 mL | 25.7852 mL |
| 5 mM | 0.5157 mL | 2.5785 mL | 5.1570 mL |
| 10 mM | 0.2579 mL | 1.2893 mL | 2.5785 mL |
| 50 mM | 0.0516 mL | 0.2579 mL | 0.5157 mL |
Description
VER-49009 (CCT0129397) is a potent inhibitor with of 47 nM for HSP90β.
Targets
| HSP90β [1] |
| 47 nM |
In vitro
VER-49009 inhibits the intrinsic ATPase activity of recombinant yeast Hsp90 with IC50 of 167 nM, and produces antiproliferative activity in a panel of human cancer cell lines and nontumorigenic cells in vitro. VER-49009 causes induction of HSP72 and HSP27 with depletion of client proteins, including C-RAF, B-RAF, and survivin, and PRMT5, which further result in cell cycle arrest and apoptosis. VER-49009 inhibits the cell proliferation, and induces G2 phase arrest in hepatic stellate cell line CFSC cells, which may suggest a rational approach in the prevention of liver fibrosis.
In vivo
In athymic mice, VER-49009 (20 mg/kg, i.v.) shows rapid clearance with values of 0.187 L/h. In an orthotopic human ovarian carcinoma model, VER-49009 (4 mg/kg, i.p.) also induces the depletion of the sensitive HSP90 client protein ERBB2.
References
Powered by Arctom Copyright © 2025 Arctom.
All rights reserved.