[CAS NO. 838818-26-1] WIKI4
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PRODUCTS SPECIFICATIONS [838818-26-1]
Catalog
SLK-S7490
Brand
Selleck
CAS
838818-26-1
DESCRIPTION [838818-26-1]
Overview
| MDL | MFCD05885187 |
|---|---|
| Molecular Weight | 521.59 |
| Molecular Formula | C29H23N5O3S |
| SMILES | O=C1N(CCCSC2=NN=C(C3=CC=NC=C3)N2C4=CC=C(OC)C=C4)C(C5=CC=CC6=CC=CC1=C56)=O |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.9172 mL | 9.5861 mL | 19.1721 mL |
| 5 mM | 0.3834 mL | 1.9172 mL | 3.8344 mL |
| 10 mM | 0.1917 mL | 0.9586 mL | 1.9172 mL |
| 50 mM | - | - | - |
Description
WIKI4 is a novel inhibitor with of 15 nM for TNKS2, and leads to inhibition of signaling.
Targets
| TNKS2 [1] |
| 15 nM |
In vitro
WIKI4 inhibitsWnt/ß-catenin signaling in all tested cell lines, including A375, DLD1 colorectal cancer, NALM6 B, U2OS osteosarcoma and hESCs. WIKI4 increases the steady-state abundance of theWnt/ß-catenin inhibitory protein, AXIN1 by inhibiting tankyrase activity, and thus preventing the ubiquitylation and degradation of AXIN proteins.
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