[CAS NO. 313553-47-8] INH1
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PRODUCTS SPECIFICATIONS [313553-47-8]
Catalog
SLK-S7493
Brand
Selleck
CAS
313553-47-8
DESCRIPTION [313553-47-8]
Overview
| MDL | MFCD01356769 |
|---|---|
| Molecular Weight | 308.40 |
| Molecular Formula | C18H16N2OS |
| SMILES | CC1=C(C=2N=C(NC(=O)C3=CC=CC=C3)SC2)C=CC(C)=C1 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.2425 mL | 16.2127 mL | 32.4254 mL |
| 5 mM | 0.6485 mL | 3.2425 mL | 6.4851 mL |
| 10 mM | 0.3243 mL | 1.6213 mL | 3.2425 mL |
| 50 mM | 0.0649 mL | 0.3243 mL | 0.6485 mL |
Description
INH1 (IBT 13131) is a cell-permeable inhibitor, which specifically disrupts the Hec1/Nek2 interaction.
Targets
| Hec1 [1] |
In vitro
INH1 reduces the association of Hec1 with kinetochore and decreases global Nek2 protein level in cells. INH1 effectively inhibits the proliferation of human breast cancer lines with GI50 of 10-21 μM. Moreover, INH1 also elicits cell killing activity in part through impairing the Hec1/Nek2 pathway for the spindle checkpoint regulation.
In vivo
INH1 (100 mg/kg i.p.) inhibits breast tumor growth in mice bearing MDA-MB-468 human breast cancer xenograft.
Synonyms
Benzamide, N-[4-(2,4-dimethylphenyl)-2-thiazolyl]-
N-[4-(2,4-Dimethylphenyl)-2-thiazolyl]benzamide
IBT 13131
INH 1
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