[CAS NO. 1001753-24-7] INH6
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PRODUCTS SPECIFICATIONS [1001753-24-7]
Catalog
SLK-S7494
Brand
Selleck
CAS
1001753-24-7
DESCRIPTION [1001753-24-7]
Overview
| MDL | MFCD04722622 |
|---|---|
| Molecular Weight | 322.42 |
| Molecular Formula | C19H18N2OS |
| SMILES | O=C(NC1=NC(C2=C(C)C=C(C)C=C2C)=CS1)C3=CC=CC=C3 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.1015 mL | 15.5077 mL | 31.0154 mL |
| 5 mM | 0.6203 mL | 3.1015 mL | 6.2031 mL |
| 10 mM | 0.3102 mL | 1.5508 mL | 3.1015 mL |
| 50 mM | 0.0620 mL | 0.3102 mL | 0.6203 mL |
Description
INH6 is a potent inhibitor, which specifically disrupts the Hec1/Nek2 interaction and causes chromosome mis-alignment.
Targets
| Hec1 [1] |
In vitro
INH6 effectively targets the Hec1/Nek2 complex for degradation, and shows potent cell killing activity with IC50 of 1.7, 2.1, 2.4, and 2.5 μM in MDA-MB231, MDA-MB468, HeLa and K562 cell lines. INH6 also triggers mitotic abnormalities in HeLa cells, and induces apoptosis.
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