[CAS NO. 1334921-03-7] TAI-1

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PRODUCTS SPECIFICATIONS [1334921-03-7]

Catalog

SLK-S7495

Brand

Selleck

CAS

1334921-03-7

DESCRIPTION [1334921-03-7]

Overview

MDL	-
Molecular Weight	431.51
Molecular Formula	C24H21N3O3S
SMILES	-

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	2.3174 mL	11.5872 mL	23.1744 mL
5 mM	0.4635 mL	2.3174 mL	4.6349 mL
10 mM	0.2317 mL	1.1587 mL	2.3174 mL
50 mM	0.0463 mL	0.2317 mL	0.4635 mL

Description

TAI-1 is a potent and specific inhibitor, which disrupts Hec1-Nek2 protein interaction.

Targets

Hec1 ^[1]

In vitro

TAI-1 disrupts the binding of Nek2 to Hec1, which leads to degradation of Nek2 and chromosomal misalignment. TAI-1 shows strong growth inhibitory potency at nM levels across a broad spectrum of tumor cells, and produces synergistic activity with doxorubicin, topotecan and paclitaxel in leukemia, breast and liver cancer cells.

In vivo

TAI-1 (20 mg/kg i.v. or 150 mg/kg p.o.) causes significant tumor growth delay in Huh-7 model and modest tumor inhibition in Colo205 and MDA-MB-231 models.

References

[1] Huang LY, et al. J Exp Clin Cancer Res. 2014, 33, 6.