[CAS NO. 442632-72-6] CK-636
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PRODUCTS SPECIFICATIONS [442632-72-6]
Catalog
SLK-S7497
Brand
Selleck
CAS
442632-72-6
DESCRIPTION [442632-72-6]
Overview
| MDL | MFCD03036245 |
|---|---|
| Molecular Weight | 284.38 |
| Molecular Formula | C16H16N2OS |
| SMILES | O=C(C1=CC=CS1)NCCC2=C(C)NC3=C2C=CC=C3 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.5164 mL | 17.5821 mL | 35.1642 mL |
| 5 mM | 0.7033 mL | 3.5164 mL | 7.0328 mL |
| 10 mM | 0.3516 mL | 1.7582 mL | 3.5164 mL |
| 50 mM | 0.0703 mL | 0.3516 mL | 0.7033 mL |
Description
CK-636 (CK-0944636) is an complex inhibitor with of 4 μM, 24 μM and 32 μM for inhibition of actin polymerization induced by human, fission yeast and bovine Arp2/3 complex, respectively.
Targets
In vitro
CK-636 inhibits actin polymerization mediated by Arp2/3 complex in live cells, and reduces the formation of actin filament comet tails by Listeria in infected SKOV3 cells. CK-636 inhibits lamellipodia formation at the leading edges of migrating T cells, and causes reduced velocity. In addition, a substantial fraction of CK-636-treated T cells on zigzag patterns with an acute turning angle are trapped near the interfaces formed by the turning points of zigzag patterns.
References
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