[CAS NO. 1572414-83-5] ML323
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PRODUCTS SPECIFICATIONS [1572414-83-5]
Store
Catalog
SLK-S7529
Brand
Selleck
CAS
1572414-83-5
DESCRIPTION [1572414-83-5]
Overview
| MDL | MFCD28099817 |
|---|---|
| Molecular Weight | 384.48 |
| Molecular Formula | C23H24N6 |
| SMILES | CC(C1=CC=CC=C1C2=NC=C(C)C(NCC3=CC=C(N4N=NC=C4)C=C3)=N2)C |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Description
ML323 displays reversible, nanomolar inhibitory activity and excellent selectivity toward with IC50 of 76 nM.
Features
USP1-UAF1-selective inhibitor.
Targets
| USP1-UAF1 [1] (Cell-free assay) |
| 76 nM |
In vitro
ML323 inhibits the deubiquitination of PCNA and FANCD2 by inhibiting USP1–UAF1 activity in H596 cells. Moreover, ML323 potentiates cisplatin cytotoxicity in NSCLC H596 cells and U2OS osteosarcoma cells by targeting two major DNA damage response pathways (TLS and FA).
References
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