[CAS NO. 1527503-11-2] A-366
Please click "REQUEST A QUOTE" button if you need other sizes or
custom synthesis
request a quote
If there is no stock, or you need other sizes or custom synthesis,
please:
PRODUCTS SPECIFICATIONS [1527503-11-2]
Catalog
SLK-S7572
Brand
Selleck
CAS
1527503-11-2
DESCRIPTION [1527503-11-2]
Overview
| MDL | MFCD28133403 |
|---|---|
| Molecular Weight | 329.44 |
| Molecular Formula | C19H27N3O2 |
| SMILES | NC(C12CCC1)=NC3=C2C=C(OC)C(OCCCN4CCCC4)=C3 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.0355 mL | 15.1773 mL | 30.3545 mL |
| 5 mM | 0.6071 mL | 3.0355 mL | 6.0709 mL |
| 10 mM | 0.3035 mL | 1.5177 mL | 3.0355 mL |
| 50 mM | 0.0607 mL | 0.3035 mL | 0.6071 mL |
Description
A-366 is a potent and selective inhibitor with of 3.3nM and 38nM, exhibiting >1000-fold selectivity for G9a/GLP over 21 other methyltransferases.
Targets
| G9a/GLP [2] (Cell-free assay) |
| 3.3 nM |
In vitro
A-366 has significantly less cytotoxic effects on the growth of tumor cell lines compared to other known G9a/GLP small molecule inhibitors despite equivalent cellular activity on methylation of H3K9me2. Treatment of various leukemia cell lines in vitro results in marked differentiation and morphological changes of these tumor cell lines.
References
Powered by Arctom Copyright © 2025 Arctom.
All rights reserved.