[CAS NO. 1793053-37-8] LLY-507
Please click "REQUEST A QUOTE" button if you need other sizes or
custom synthesis
request a quote
If there is no stock, or you need other sizes or custom synthesis,
please:
PRODUCTS SPECIFICATIONS [1793053-37-8]
Catalog
SLK-S7575
Brand
Selleck
CAS
1793053-37-8
DESCRIPTION [1793053-37-8]
Overview
| MDL | - |
|---|---|
| Molecular Weight | 574.76 |
| Molecular Formula | C36H42N6O |
| SMILES | - |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.7399 mL | 8.6993 mL | 17.3986 mL |
| 5 mM | 0.3480 mL | 1.7399 mL | 3.4797 mL |
| 10 mM | 0.1740 mL | 0.8699 mL | 1.7399 mL |
| 50 mM | 0.0348 mL | 0.1740 mL | 0.3480 mL |
Description
LLY-507 is a cell-active, potent, and selective inhibitor of protein-lysine Methyltransferase .
Targets
| SMYD2 [1] |
In vitro
LLY-507 potently inhibits the ability of SMYD2 to methylate p53 peptide with an IC50 <15 nM. LLY-507 is able to potently inhibit the methylation of H4 peptide by SMYD2 enzyme with an IC50 of 31 nM. It has 100-fold selectivity for SMYD2 over 24 other protein or DNA methyltransferases including related family members SMYD3, SUVH420H1, and SUV420H2. LLY-507 inactives (>20 μM) against 454 kinases, 35 G protein-coupled receptors, 14 nuclear hormone receptors, and three cytochrome P450 enzymes. LLY-507 inhibits the proliferation of several esophageal, liver, and breast cancer cell lines in a dose-dependent manner.
Powered by Arctom Copyright © 2025 Arctom.
All rights reserved.