[CAS NO. 16611-84-0] Anacardic Acid

Name: Anacardic Acid
Brand: Arctom Scientific
SKU: SLK-S7582

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PRODUCTS SPECIFICATIONS [16611-84-0]

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Catalog

SLK-S7582

Brand

Selleck

CAS

16611-84-0

DESCRIPTION [16611-84-0]

Overview

MDL	MFCD07368254
Molecular Weight	348.52
Molecular Formula	C22H36O3
SMILES	C(O)(=O)C1=C(CCCCCCCCCCCCCCC)C=CC=C1O

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	2.8693 mL	14.3464 mL	28.6928 mL
5 mM	0.5739 mL	2.8693 mL	5.7386 mL
10 mM	0.2869 mL	1.4346 mL	2.8693 mL
50 mM	0.0574 mL	0.2869 mL	0.5739 mL

Description

Anacardic Acid (6-pentadecylsalicylic Acid) is a potent inhibitor of , which also has antibacterial activity, antimicrobial activity, prostaglandin synthase inhibition, and tyrosinase and lipoxygenase inhibition.

Targets

Tip60 ^[2] (Cell-free assay)	PCAF ^[1] (Cell-free assay)	p300/CBP ^[1] (Cell-free assay)
	5 μM	8.5 μM

In vitro

Anacardic acid is found to be a common inhibitor of several clinically targeted enzymes such as NFkB kinase, histone acetyltransferase (HATs), lipoxygenase (LOX-1), xanthine oxidase, tyrosinase and ureases. Anacardic acid is also an efficient inhibitor of Tip60 in vitro.It inhibits the Tip60-dependent acetylation and activation of the ATM protein kinase in HeLa cells, and sensitizes the cells to the cytotoxic effects of radiation. Anacardic acid can effectively prevent cell damage induced by H2O2 because this can be converted to ROS, hydroxyl radicals, in the presence of metal ions.

In vivo

Anacardic acid attenuates over-expression of Gata4, α-MHC and cTnT in fetal mouse hearts exposed to ethanol. Anacardic acid inhibits binding of P300, PCAF to the promoter of Gata4.

References

[1] Balasubramanyam K, et al. J Biol Chem,2003,278(21):19134-40.
[2] Sun Y, et al. FEBS Lett. 2006, 580(18):4353-4356.
[3] Peng C, et al. PLoS One. 2014, 9(8):e104135.
[4] Hemshekhar M, et al. Basic Clin Pharmacol Toxicol. 2012, 110(2):122-132.

Synonyms

Benzoic acid, 2-hydroxy-6-pentadecyl-

Salicylic acid, 6-pentadecyl-

2-Hydroxy-6-pentadecylbenzoic acid

1-Hydroxy-2-carboxy-3-pentadecylbenzene

(15:0)-Anacardic acid

6-Pentadecylsalicylic acid

Cyclogallipharic acid

Hydroginkgolic acid

22:0-Anacardic acid

NSC 229596

NSC 333857

NSC 623096

6-Pentadecyl-2-hydroxybenzoic acid

Hydrogenated anacardic acid

Ginkgolic acid C15:0