[CAS NO. 1418308-27-6] EI1

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PRODUCTS SPECIFICATIONS [1418308-27-6]

Catalog

SLK-S7611

Brand

Selleck

CAS

1418308-27-6

DESCRIPTION [1418308-27-6]

Overview

MDL	MFCD25976740
Molecular Weight	390.48
Molecular Formula	C23H26N4O2
SMILES	C(CC)(CC)N1C=2C(=C(C(NCC3=C(C)C=C(C)NC3=O)=O)C=C(C#N)C2)C=C1

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Description

EI1 is a potent and selective inhibitor with of 15 nM and 13 nM for EZH2 (WT) and EZH2 (Y641F), respectively.

Targets

EZH2 (Y641F) ^[1] (Cell-free assay)	Ezh2 (wild-type) ^[1] (Cell-free assay)
13 nM	15 nM

In vitro

In DLBCL cells, EI1 inhibits cellular H3K27 methylation and activates Ezh2 target gene p16 expression. In mouse embryonic fibroblasts, EI1 also inhibit H3K27me3 and cell proliferation. In addition, EI1 selectively inhibits the growth of DLBCL cells carrying Ezh2 mutation, and causes cell cycle arrest and apoptosis.

References

[1] Qi W, et al. Proc Natl Acad Sci U S A. 2012, 109(52), 21360-21365.

Synonyms

1H-Indole-4-carboxamide, 6-cyano-N-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-1-(1-ethylpropyl)-

6-Cyano-N-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-1-(1-ethylpropyl)-1H-indole-4-carboxamide

EI 1

EL 1