[CAS NO. 685898-44-6] PX-478 2HCl

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PRODUCTS SPECIFICATIONS [685898-44-6]

Catalog

SLK-S7612

Brand

Selleck

CAS

685898-44-6

DESCRIPTION [685898-44-6]

Overview

MDL	MFCD11840749
Molecular Weight	394.12
Molecular Formula	C13H20Cl4N2O3
SMILES	N(CCCl)(CCCl)(=O)C1=CC=C(C[C@@H](C(O)=O)N)C=C1.Cl

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	2.5373 mL	12.6865 mL	25.3730 mL
5 mM	0.5075 mL	2.5373 mL	5.0746 mL
10 mM	0.2537 mL	1.2686 mL	2.5373 mL
50 mM	0.0507 mL	0.2537 mL	0.5075 mL

Description

PX-478 2HCl is an orally active, and selective inhibitor. PX-478 2HCl induces and has anti-tumor activity. Phase 1.

Targets

HIF-1α ^[1]

In vitro

PX-478 lowers HIF-1α protein levels and HIF-1 transactivation in hypoxia and in normoxia in a variety of cancer cell lines, but has a more pronounced effect on translation of proteins, such as HIF-1α in hypoxia. PX-478 also enhances the radiosensitivity of prostate carcinoma PC3 cells.

References

[1] Welsh S, et al. Mol Cancer Ther. 2004, 3(3), 233-244.
[2] Koh MY, et al. Mol Cancer Ther. 2008, 7(1), 90-100.
[3] Palayoor ST, et al. Int J Cancer. 2008, 123(10), 2430-2437.
[4] Sun K, et al. Mol Cell Biol. 2013, (5), 904-917.
[5] Xiang T, et al. Nat Commun. 2018 Nov 27;9(1):5009.

Synonyms

L-Phenylalanine, 4-[bis(2-chloroethyl)oxidoamino]-, hydrochloride (1:2)

L-Phenylalanine, 4-[bis(2-chloroethyl)oxidoamino]-, dihydrochloride

PX 478

(S)-4-(2-Amino-2-carboxyethyl)-N,N-bis(2-chloroethyl)aniline oxide dihydrochloride