[CAS NO. 1271738-62-5] MI-2 (Menin-MLL Inhibitor)
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PRODUCTS SPECIFICATIONS [1271738-62-5]
Catalog
SLK-S7618
Brand
Selleck
CAS
1271738-62-5
DESCRIPTION [1271738-62-5]
Overview
| MDL | MFCD22575021 |
|---|---|
| Molecular Weight | 375.55 |
| Molecular Formula | C18H25N5S2 |
| SMILES | CCCC1=CC2=C(N3CCN(C4=NCC(C)(C)S4)CC3)N=CN=C2S1 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.6628 mL | 13.3138 mL | 26.6276 mL |
| 5 mM | 0.5326 mL | 2.6628 mL | 5.3255 mL |
| 10 mM | 0.2663 mL | 1.3314 mL | 2.6628 mL |
| 50 mM | 0.0533 mL | 0.2663 mL | 0.5326 mL |
Description
MI-2 (Menin-MLL Inhibitor) is a potent interaction inhibitor with of 446 nM.
Targets
| Menin-MLL interaction [1] (Cell-free assay) |
| 446 nM |
In vitro
In HEK293 cells, MI-2 accessed the protein target and effectively inhibits the menin-MLL-AF9 interaction. MI-2 effectively blocks MLL fusion protein-mediated leukemic transformation by downregulating the expression of target genes required for MLL fusion protein oncogenic activity. MI-2 also effectively blocks cell proliferation, and induces cell apoptosis in human MLL leukemia cell lines harboring different MLL translocations.
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