[CAS NO. 1361030-48-9] LDC1267
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PRODUCTS SPECIFICATIONS [1361030-48-9]
Catalog
SLK-S7638
Brand
Selleck
CAS
1361030-48-9
DESCRIPTION [1361030-48-9]
Overview
| MDL | MFCD28385861 |
|---|---|
| Molecular Weight | 560.55 |
| Molecular Formula | C30H26F2N4O5 |
| SMILES | O=C(C1=NN(C2=CC=C(F)C=C2C)C=C1OCC)NC3=CC=C(OC4=CC=NC5=CC(OC)=C(OC)C=C45)C(F)=C3 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Description
LDC1267 is a highly selective inhibitor with of <5 nM, 8 nM, and 29 nM for Mer, Tyro3, and Axl, respectively. Displays lower activity against Met, Aurora B, Lck, Src, and CDK8.
In vitro
LDC1267 moderately affects cell proliferation in 11 of 95 different cell lines with IC50 of >5μM. In NKG2D-activated NK cells, LDC1267 abolishes the inhibitory effects of Gas6 stimulation.
In vivo
In B16F10 melanoma-bearing mice, LDC1267 (20 mg/kg, i.p.) efficiently enhances anti-metastatic NK cell activity, and rejects tumor metastases without serious cytotoxicity.
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