[CAS NO. 474645-27-7] Monomethyl auristatin E (MMAE)

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PRODUCTS SPECIFICATIONS [474645-27-7]

Catalog

SLK-S7721

Brand

Selleck

CAS

474645-27-7

DESCRIPTION [474645-27-7]

Overview

MDL	MFCD22124498
Molecular Weight	717.98
Molecular Formula	C39H67N5O7
SMILES	[C@H]([C@H](C(N[C@@H]([C@@H](O)C1=CC=CC=C1)C)=O)C)(OC)[C@]2(N(C(C[C@H]([C@@H](N(C([C@@H](NC([C@H](C(C)C)NC)=O)[C@@H](C)C)=O)C)[C@H](CC)C)OC)=O)CCC2)[H]

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	1.3928 mL	6.9640 mL	13.9280 mL
5 mM	0.2786 mL	1.3928 mL	2.7856 mL
10 mM	0.1393 mL	0.6964 mL	1.3928 mL
50 mM	0.0279 mL	0.1393 mL	0.2786 mL

Description

Monomethyl auristatin E (MMAE, SGD-1010) is a synthetic antineoplastic agent, which is linked to a monoclonal antibody (MAB). It is also a microtubule-disrupting agent .

In vitro

When coupled to cAC10, MMAE shows selective cytotoxicity in CD30 cells, and induces G2/M-phase growth arrest and cell death through the induction of apoptosis. When coupled to anti-CD79b antibody, anti–CD79b-vcMMAE has very potent and broad activity across a large panel of NHL cell lines in vitro. When coupled to anti-HER2 antibody, hertuzumab-vc-MMAE can also be effectively internalized and potently kill HER2 over-expressing tumor cells.

References

[1] Francisco JA, et al. Blood. 2003, 102(4), 1458-1465.
[2] Dornan D, et al. Blood. 2009, 114(13), 2721-2729.
[3] Yao X, et al. Breast Cancer Res Treat. 2015, 153(1), 123-133.
[4] Wang S, et al. Cancer Lett. 2017 Nov 28;409:125-136.

Synonyms

L-Valinamide, N-methyl-L-valyl-N-[(1S,2R)-4-[(2S)-2-[(1R,2R)-3-[[(1R,2S)-2-hydroxy-1-methyl-2-phenylethyl]amino]-1-methoxy-2-methyl-3-oxopropyl]-1-pyrrolidinyl]-2-methoxy-1-[(1S)-1-methylpropyl]-4-oxobutyl]-N-methyl-

N-Methyl-L-valyl-N-[(1S,2R)-4-[(2S)-2-[(1R,2R)-3-[[(1R,2S)-2-hydroxy-1-methyl-2-phenylethyl]amino]-1-methoxy-2-methyl-3-oxopropyl]-1-pyrrolidinyl]-2-methoxy-1-[(1S)-1-methylpropyl]-4-oxobutyl]-N-methyl-L-valinamide

MMAE

Monomethylauristatin E

Monomethylauristatin norephedrine

Toxin MMAE

MMAE toxin

Monomethyl auristatin E