[CAS NO. 307543-71-1] STF-083010
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PRODUCTS SPECIFICATIONS [307543-71-1]
Catalog
SLK-S7771
Brand
Selleck
CAS
307543-71-1
DESCRIPTION [307543-71-1]
Overview
| MDL | MFCD02332975 |
|---|---|
| Molecular Weight | 317.38 |
| Molecular Formula | C15H11NO3S2 |
| SMILES | C(=NS(=O)(=O)C1=CC=CS1)C=2C3=C(C=CC2O)C=CC=C3 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.1508 mL | 15.7540 mL | 31.5080 mL |
| 5 mM | 0.6302 mL | 3.1508 mL | 6.3016 mL |
| 10 mM | 0.3151 mL | 1.5754 mL | 3.1508 mL |
| 50 mM | 0.0630 mL | 0.3151 mL | 0.6302 mL |
Description
STF-083010 is a specific inhibitor without affecting its kinase activity.
Targets
| IRE1α endonuclease [1] |
In vitro
In RPMI 8226, MM.1S, and MM.1R MM cell lines, STF-083010 exhibits cytostatic and cytotoxic activity in a dose and time dependent manner. In MiaPaCa2, Panc0403, and SU8686 cell lines, STF-083010 inhibits XBP1 splicing and blocks IRE1α's endonuclease activity without affecting its kinase activity. In Eμ-TCL1 CLL cells, STF-083010 exhibits about 70% growth inhibition after 3 days culture. In MEC1 and MEC2 cells, STF-083010 produces 20% growth inhibition in 48 h. WaC3 cells respond to treatments with STF-083010 with gradually decreased growth.
In vivo
In human multiple myeloma (MM) xenografts model, STF-083010 (i.p., 30 mg/kg) significantly inhibits the growth of tumor.
References
Synonyms
2-Thiophenesulfonamide, N-[(2-hydroxy-1-naphthalenyl)methylene]-
N-[(2-Hydroxy-1-naphthalenyl)methylene]-2-thiophenesulfonamide
STF 083010
IRE 1 Inhibitor I
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