[CAS NO. 1431326-61-2] Iadademstat (ORY-1001) 2HCl
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PRODUCTS SPECIFICATIONS [1431326-61-2]
Catalog
SLK-S7795
Brand
Selleck
CAS
1431326-61-2
DESCRIPTION [1431326-61-2]
Overview
| MDL | MFCD28900684 |
|---|---|
| Molecular Weight | 303.27 |
| Molecular Formula | C15H22N2 . 2HCl |
| SMILES | NC1CCC(N[C@H]2[C@H](C3=CC=CC=C3)C2)CC1.[H]Cl.[H]Cl |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.2974 mL | 16.4870 mL | 32.9739 mL |
| 5 mM | 0.6595 mL | 3.2974 mL | 6.5948 mL |
| 10 mM | 0.3297 mL | 1.6487 mL | 3.2974 mL |
| 50 mM | 0.0659 mL | 0.3297 mL | 0.6595 mL |
Description
ORY-1001 (RG-6016) 2HCl is an orally active and selective lysine-specific demethylase inhibitor with of <20 nM, with high selectivity against related FAD dependent aminoxidases. Phase 1.
Targets
| LSD1 [1] |
| 20 nM |
In vitro
In THP-1 (MLL-AF9) cells, ORY-1001 results in a time/dose dependent me2H3K4 accumulation at KDM1A target genes and concomitant induction of differentiation markers. ORY-1001 also induces apoptosis in THP-1 and inhibits proliferation and colony formation of MV(4;11) (MLL-AF4) cells.
References
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