[CAS NO. 103404-90-6] Disodium (R)-2-Hydroxyglutarate

Name: Disodium (R)-2-Hydroxyglutarate
Brand: Arctom Scientific
SKU: SLK-S7873

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PRODUCTS SPECIFICATIONS [103404-90-6]

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Catalog

SLK-S7873

Brand

Selleck

CAS

103404-90-6

DESCRIPTION [103404-90-6]

Overview

MDL	MFCD00069573
Molecular Weight	192.08
Molecular Formula	C5H6Na2O5
SMILES	[C@@H](CCC(O)=O)(C(O)=O)O.[Na]

For research use only.

Storage

3 years,-20°C,powder
1 years,-80°C,in solvent

Shipping

Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)

Preparing Stock Solutions

Concentration Volume Mass	1 mg	5 mg	10 mg
1 mM	5.2062 mL	26.0308 mL	52.0616 mL
5 mM	1.0412 mL	5.2062 mL	10.4123 mL
10 mM	0.5206 mL	2.6031 mL	5.2062 mL
50 mM	0.1041 mL	0.5206 mL	1.0412 mL

Description

Disodium (R)-2-Hydroxyglutarate (D-α-Hydroxyglutaric acid disodium) is a competitive inhibitor of with of 10.87 ± 1.85 mM.

Targets

α-ketoglutarate-dependent dioxygenase ^[1]

In vitro

In U-87MG cells, (R)-2-Hydroxyglutarate acts as weak antagonists of α-KG to inhibit α-KG-dependent histone demethylases and increases dimethylation on both H3K9 and H3K79. Besides, (R)-2-Hydroxyglutarate inhibits ATP synthase and mTOR signaling, and thus causes growth arrest and tumor cell killing.

References

[1] Xu W, et al. Cancer Cell. 2011, 19(1), 17-30.
[2] Kim SY, et al. Cardiovasc Res. 2011, 92(2), 307-316.

Synonyms

Pentanedioic acid, 2-hydroxy-, sodium salt (1:2), (2R)-

Pentanedioic acid, 2-hydroxy-, disodium salt, (R)-

Pentanedioic acid, 2-hydroxy-, disodium salt, (2R)-