[CAS NO. 832115-62-5] Isoxazole 9 (ISX-9)
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PRODUCTS SPECIFICATIONS [832115-62-5]
Catalog
SLK-S7914
Brand
Selleck
CAS
832115-62-5
DESCRIPTION [832115-62-5]
Overview
| MDL | MFCD04133937 |
|---|---|
| Molecular Weight | 234.27 |
| Molecular Formula | C11H10N2O2S |
| SMILES | O=C(C1=NOC(C2=CC=CS2)=C1)NC3CC3 |
For research use only.
Storage
3 years,-20°C,powder
1 years,-80°C,in solvent
1 years,-80°C,in solvent
Shipping
Room temperature shipping(Stability testing shows this product can be shipped without any cooling measures.)
Preparing Stock Solutions
| 1 mg | 5 mg | 10 mg | |
| 1 mM | 4.2686 mL | 21.3429 mL | 42.6858 mL |
| 5 mM | 0.8537 mL | 4.2686 mL | 8.5372 mL |
| 10 mM | 0.4269 mL | 2.1343 mL | 4.2686 mL |
| 50 mM | 0.0854 mL | 0.4269 mL | 0.8537 mL |
Description
Isoxazole 9 (Isx-9) is a synthetic promotor of adult neurogenesis by triggering neuronal differentiation of adult neural stem/precursor cells (NSPCs). Isoxazole 9 (Isx-9) activates multiple pathways including induced epithelial–mesenchymal transition (EMT) signaling, canonical and non-canonical signaling at different stages of cardiac differentiation.
In vitro
In NSPCs, isoxazole 9 increases cell number, and promotes cell differentiation. In OPCs, isoxazole 9 induces cell damage. In outgrowth EPCs, isoxazole 9 decreases tube formation without effect on early EPCs.
In vivo
In mice, isoxazole 9 (20 mg/kg, i.p.) crosses the BBB and increases proliferation of neuroblasts and neurogenesis via Mef2-specific mechanisms in the hippocampal SGZ. Isoxazole 9 (20 mg/kg, i.p.) also increases differentiation and dendritic complexity of immature neurons and improves memory. In MWM, isoxazole 9 improves spatial memory.
References
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